Sentence examples for a considerably lower affinity from inspiring English sources

ERβ-503 has an 18 amino acid residue in frame insertion into the LBD, and has a considerably lower affinity for E2 than ERβ-485.

As vortioxetine has a considerably lower affinity for rat, compared with human, 5-HT1A recepTable(Table 2011), combined treatments with flesinoxan (2.5 mg·kg−1) were included to mimic 5-HT1A occupancy in clinical settings.

Consequently, AtCERK1 binds (GlcNAc 6 with a considerably lower affinity (kd = 44.8 µM; Liu et al., 2012) than the LysM1 LysM3 binding groove of Ecp6 (kd = 280 pM; Figure 7B).

To determine if TCR affinity influences the onset of EAE, we identified and cloned a TCR that has considerably lower affinity for the Ac1-11 MBpeptidede presented by I-Au as compared to a previously published TCR [14].

In addition, GST-AS protein showed considerably lower affinity for acetazolamine, a sulphonamide inhibitor of carbonic anhydrases: Ki WT=14 n M vs Ki AS=110 n M.

However, despite its considerably lower affinity for CEA (Kd, 10 n M vs 20 p M), ghPR1A3 was found to be equally effective at prolonging survival when compared with SM3E.

Chd1 proteins from which the SANT-SLIDE domains have been ablated by mutation or deletion have considerably lower affinity for DNA or nucleosomes (Grüne et al., 2003; Ryan et al., 2011).

P66 binds to αvβ3 with an affinity on the order of that of a vitronectin-derived 15-aminoacid peptide containing the RGD sequence (the KD for vitronectin was not measurable due to multiple interactions) (Orlando and Cheresh, 1991), and as shown in Table 1, the site-directed mutant P66 proteins bind with considerably lower affinity.

Previously, we showed that VV F1L exhibited a highly selective BH3-domain ligand-binding profile, with high affinity for pro-apoptotic Bim (KD=200 nM), and considerably lower affinity for Bax and Bak BH3 domains (KD of 2000 and 4300 nM, respectively).

The mutations E77A, R159E, K161E and N191R slightly decreased the nucleotide binding affinity (Additional file 6) but it is unlikely that this caused the loss of oligomerisation because the G4-motif mutant, Irga6-D186N, with a considerably lower binding affinity for guanine nucleotides, oligomerised relatively efficiently in the presence of GTP (see below).

Cytochromes bo′ and bd-II also have considerably lower affinities for oxygen than bd-I.