The phrase "a considerably higher dose" is correct and usable in written English.
It can be used when discussing medication, treatment, or any context where dosage levels are being compared.
Example: "The doctor recommended a considerably higher dose of the medication to achieve the desired effect."
Alternatives: "a significantly larger dose" or "a much greater dose".
In collagen- and adjuvant-induced arthritis, the combination had an equipotent anti-inflammatory action compared with a considerably higher dose of prednisolone alone.
However, 15 months post IR a drastic demyelination was observed (46% decrease compared with controls), albeit after a considerably higher dose (25 Gy).
In contrast, the present data show that a considerably higher dose of methylprednisolone (500 μg, equivalent to about 1500 μg/kg) despite completely suppressing corticosterone secretion failed to block the response to exogenous CRH.
Given that a considerably higher dose of oxaliplatin compared with cisplatin can be given in IPC, the platinum of choice for IPC in PMP to achieve maximum effect is suggested to be oxaliplatin.
NanoCluster budesonide (NC-Bud) formulations had a considerably higher emitted dose and fine particle fraction compared with stock budesonide and the commercial Flexhaler powder when applied through endotracheal tubes.
Nitroglycerin, though at a considerably higher systemic dose (10 mg/kg) as in the present study, has been shown to activate the transcription factor NF-κB [28] and the calmodulin dependent protein kinase II alpha (CamKIIα) [29] in the rat spinal trigeminal nucleus, which could explain transcriptional effects causing long-term neuronal changes.
However, HR CT is associated with a considerably higher radiation dose compared with the X-ray examinations commonly used in routine clinical practice for the estimation of bone status.
This is particularly an issue for preclinical studies like toxicological trials, in which considerably higher doses and volumes are being administered compared to clinical studies.
Thus, that optimal silencing in 9L cells at 48 hrs can be achieved between MOI 1.0 and 5.0, i.e. at considerably higher doses than those needed to achieve near complete silencing in a highly susceptible cell line.
Considerably higher doses of artesunate are needed to produce neurotoxicity in animals.
