BE induces cell death more rapidly as compared to BetA, but to achieve similar amounts of cell death a considerably higher concentration of BE is needed.
As shown in Fig. S1, NSC321206 effectively eliminated all MDA-MB-231 cells at a concentration of 1 µM (GI50 value of 0.4 µM), while the non-malignant breast epithelial cell line (MCF10A) were only partially affected, at a considerably higher concentration of this compound.
L-000870812, showed activity against XMRV replication at considerably higher concentrations, with an EC50 and EC90 of 0.16 µM and 26.9 µM in MCF-7 cells, and 0.7 µM and 4.5 µM in LNCaP cells, respectively.
The only exception was LK1, which needed considerably higher concentrations to cause a similar effect.
Considerably higher concentrations were detected in a recent study [18] in the north-eastern Pacific and close to the coast of British Columbia Canadaa).
The lowest dose inducing a cytopathic effect in L929 fibroblasts has not been reported, but at doses of 10 μM and 16 μM, it has ∼50% cytopathicity (Chany et al., 2011; Guenin-Mace et al., 2015) and considerably higher concentrations (16 μM vs. 26 nM) were required to have a similar impact on the attachment/spreading of cells on a tissue culture surface (Chany et al., 2014).
Interestingly, the mutants were able to grow and to produce macedocin at considerably higher concentrations of NaCl compared to the wild-type (up to 4.0% w/v).
In that case even for much lower VES equimolar concentrations (1.5 mM) the viscosity contrast was 5 which is two times higher than observed in capillaries in the current studies at considerably higher concentrations (7.5/5 mM).
There is an incongruity between the low solubility of Taxol in aqueous solution and the considerably higher concentrations at which the drug is often used.
They were also active at the CB1 receptor, but required considerably higher concentrations than AEA.
