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Discover LudwigThe phrase "a considerable unknown" is correct and usable in written English.
It can be used to refer to a significant amount of uncertainty or lack of information about a particular subject or situation.
Example: "In the realm of scientific research, there remains a considerable unknown regarding the long-term effects of the new drug."
Alternatives: "a significant uncertainty" or "a substantial mystery".
Exact(1)
"Both candidates present a considerable unknown for business," says John J. Castellani, president of the Business Roundtable, a corporate advocacy group made up of chief executives overseeing companies that collectively generate $4.5 trillion in sales, employ 10 million workers and pay 40percentt of all corporate income taxes in the country.
Similar(59)
75%% of these service providers and a considerable – but unknown – share of dialysis machines are concentrated in Dar es Salaam, the former capital of the country.
The bin Laden tape injected another considerable unknown into the final days of a race that has rotated largely around terrorism and the Iraq war, with relatively little discussion of issues as important as the future of the Social Security or Medicare programs.
Jatropha hulls were composed of cellulose, hemicellulose, lignin, long-chain fatty acids, free phenolics and other considerable unknown impurities (Jiang et al. 2012).
This finding suggests that a considerable number of unknown carriers might be circulating in our hospital that are not subjected to contact precautions because of the unawareness of their status.
The large number of unassigned sequences from both direct and library sequencing indicates that even though this is an extreme habitat with limited phylogenetic breadth, there is a considerable amount of previously unknown metagenomic diversity in the sampled environment.
Linkle is a considerable step into the unknown for them, and I hope that she's a playable option in the next "proper" Zelda game, being teased for a 2016 Wii U release.
In addition to contigs obtained under a particular set of culture conditions (Supplementary Tables S4 S12), it is interesting that a considerable number of function-unknown genes appeared in the upper parts of Supplementary Tables S1 S3.
In particular, among those, 69 were genes of unknown function, a considerable proportion (Table 2).
Patients with adenomatous polyposis have higher risk for colorectal cancer; however causative genes remain unknown in a considerable fraction of these patients.
The amount of predicted secreted sequences associated with functional groups varied from 33.1% (M. oryzae) to 62.6% (A. niger), indicating a considerable number of proteins with unknown functions for all fungi genomes.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com