That was always going to be a considerable setback.
That was a considerable setback for an unelected, already unpopular President like Truman.
John Terry, nursing a sprained ankle, would probably not have started anyway, but Hazard's absence represents a considerable setback.
Plainly, the alternative would be a considerable setback for Van Gaal given the consistently upward trajectory of De Gea's career since those early days in Manchester when he could be a danger to his own team and Eric Steele, then United's goalkeeping coach, talked of him being a poor trainer, "lazy" when it came to learning English, and eating "too many tacos".
For Mr. Mugabe, 75, the only leader this nation of 12.5 million people has known since it achieved majority rule two decades ago, the defeat was regarded as a considerable setback, one certain to energize the growing opposition as the country prepares for parliamentary elections in April.
Paul G. Allen, who founded Microsoft with Bill Gates but left the company years ago, also had considerable setbacks in his investment portfolio this year.
With new information from a reporter on the front lines, it reported instead something far less optimistic: that allied forces had faced considerable setbacks in Karbala, about 70 miles south of Baghdad, and could even be undermanned there.
The setback last month made a considerable dent in that gain.
SETBACK FOR GARDNER Brett Gardner will not start swinging a bat for more than a week after sustaining a setback in his recovery from a right elbow injury.
In view of these considerable setbacks with the use of SARM KO mice, we strategically planned and developed a novel in vivo adoptive transfer mouse model system to study the effect of SARM knockdown during an experimental influenza infection.
