These parameters are particularly questionable when searching for diversity in a coenocytic and multinucleated organism such as AMF, where a considerable sequencing depth might be required to confirm LLMs present in the genome population.
When comparing the variable central segment of vertebrate paralogs, all NCX genes possess at least one exon that is homologous to either exon A or exon B. Indeed, exons A and B have considerable sequence homology (e.g. a central acidic region), suggesting that they arose through a duplication event early in vertebrate evolution.
Amino acid sequence alignment of human GnRHR1 with the C. elegans orthologue (Ce-GnRHR) and 3 other class A GPCRs demonstrated considerable sequence similarity (Fig. 1).
However, as DNA mutations accumulate within a tumor, there can be considerable sequence heterogeneity even within a single primary tumor [ 17].
One of the most important but also most difficult problems in computational biology is how to formulate a biological sequence with a discrete model or a vector, yet still keep considerable sequence order information.
Secondly, for a large number of genes in the T. parva Muguga reference genome, coverage with reads sequenced from the Kiambu5 genome is either partial (804) or absent (16), a result of the considerable sequence divergence observed between the two isolates.
The five candidates (BrMADS85, 87, 89, 119 and 127) that lacked a 'MADS' domain shared considerable sequence similarity with MADS-box proteins of other crop species that also lack 'MADS' domains and are considered to be MADS-box proteins (4 published and 1 unpublished MADS-box genes; Additional file 1: Table S2).
How can we formulate a peptide or protein sequence with a vector yet still keep considerable sequence order information?
Interestingly, besides being a potential miRNA*, miRNA 3-44-antisense is a homolog to miR477 sharing considerable sequence identity, even though the Physcomitrella miRNA 3-44-antisense is 24 nt in size compared to the 21 nt miR477.
