The phrase "a considerable problem of" is correct and usable in written English.
It can be used when discussing a significant issue or challenge related to a specific topic or context.
Example: "The research revealed a considerable problem of data inconsistency that needed to be addressed."
Alternatives: "a significant issue regarding" or "a major challenge related to".
There is a considerable problem of determining which of these myriad causes constitutes the conditions of correctness, rather than occasions of mistaken usage.
Due to the substantial flexibility and extended shape of the core Mediator structure, the cryo images showed a very low signal-to-noise ratio and could not be stably aligned, leading to a considerable problem of model bias in the previous cryo reconstruction of the Mediator complex.
Foundation for growth Just five years ahead of the MDG deadline, high malnutrition levels in rural parts of Syria threaten to pose a considerable problem for the future of the country.
Despite numerous initiatives to improve the working environment for nursing aides, musculoskeletal disorders (pain) is still a considerable problem because of the prevalence, and pervasive consequences on the individual, the workplace and the society.
Access to bridges, roads and tunnels will be restricted, a considerable problem when most of the population drives to and from work.
Following eradication of glanders from the Western hemisphere, false positive CFT results pose a considerable problem in trade of equids.
Olerud et al. [ 13] believe that in the cervical spine, where implant loosening is a considerable problem, the failure of support is presented mainly in cases where only anterior or only posterior stabilization was applied because the stabilizing system may not be able to confront the forces which act on it.
In developed countries, late presentation of HIV remains a considerable problem, with over 20% of patients in the UK presenting with CD4 < 200 cells/μL and therefore being at risk of OI. 1 Other patients have a suboptimal response to ART due to poor adherence to therapy, drug toxicities, and extensively drug-resistant HIV virus, so remain immunosuppressed in spite of treatment.
While the bulk of the state's homeless population is in New York City, homelessness is a considerable problem in the rest of the state.
It is clear that the TG scheme has a considerable problem with the number of required matrix inversions although it has much better system throughput and total system value results than the MA scheme.
Japan and China rank sixth and ninth respectively in issued volumes with lower article citation frequencies, which may indicate that there is a considerable problem with the quality of Japanese and Chinese papers issued.
