The structural and compositional changes seen in OA bone are likely to have considerable genetic input because there is a significant heritable component to OA, as judged by genetic studies [ 27].
Many previous studies found morphological changes to be phenotypically plastic [ 19, 52], although a few studies have demonstrated a heritable component [ 43, 53, 54].
As repeatability in a trait sets the upper limit for its heritability [ 39, 40], this suggests that FIDs may have a substantial heritable component.
This comparison considered whether a pedigree-based heritable component analysis method can identify a disease component with a chip heritability comparable to that found by our approach.
It involves 50 Finnish women treated with hormones or surgery for endometriosis, a condition that appears to have a heritable component.
Moreover, natural burrowing behaviors are recapitulated in the lab, and there is a strong heritable component.
The disease has a strong heritable component, but researchers have struggled to find the genetic culprits.
Population, family and twin studies have shown that migraine, tension-type headache and cluster headache have a significant heritable component [7, 8].
Evidence points towards the existence of a strong heritable component of human longevity [1], [2].
While telomere length is influenced by environmental factors there is also good evidence for a strong heritable component.
