Sentence examples for a considerable downregulation of from inspiring English sources

Tissue specific RNAi using various Gal4 driver lines resulted in a considerable downregulation of CycG activity as visualized by reduction of CycG mRNA and CycG protein levels (figure 3), respectively.

Regardless of the absence or presence of 3-hydroxybutyrate, we noticed a considerable downregulation of BDH, OXCT1 and ACAT1 mRNA levels in all cell lines in hypoxia.

Finally, we also detected a considerable downregulation in the levels of M6PRBP1.

Analysis of the expression differences between purified and non-purified CMs revealed considerable downregulation of early mesodermal and homeobox genes, and upregulation of cardiovascular and structural genes such as actins and extracellular collagens.

Also in strains lacking BLR1 or BLR2 considerable downregulation of transcript levels occurred [ 15].

Figure 1(b) shows the scanned ratios between ENT3 and TBP mRNA expression and confirms the very considerable downregulation of the ENT3 gene by the siRNA treatment.

A considerable sleight-of-hand.

Similarly to the transcripts that were upregulated following LPS administration, RU486 prevented the dowregulation of 25 out of 42 genes, implying that endogenous GCs are required for both upregulation and downregulation of a considerable number of genes.

In addition to SNPs and mutations, loss of heterozygosity has been shown to be an important genetic factor in human carcinomas; in the present study, complete and partial LOH and haplotype loss were found to occur in a considerable proportion of cases with ERAP1 downregulation (up to 50%).

Contrary to findings in gastric cancer, our results provide no evidence for an independent role for EZH2 in RUNX3 silencing in CRC, but nevertheless, a considerable proportion of patients with RUNX3 downregulation show both EZH2 overexpression and methylation of the RUNX3 promoter suggesting that the two processes may still be linked.

Moreover, the downregulation of ZO-1 has been associated with a considerable increase of the intestinal permeability [ 48].