The phrase "a considerable depletion" is correct and usable in written English.
It can be used to describe a significant reduction or loss of resources, materials, or quantities in various contexts.
Example: "The recent drought has led to a considerable depletion of the water supply in the region."
Alternatives: "a significant reduction" or "a substantial loss".
Under the southward IMF conditions the plasma density is enhanced over a large portion of the near-pole ionosphere as a tongue of ionization, while the northward IMF leads to a considerable depletion and occurrence of the polar hole.
The administration of 50 mg kg−1 of CY led to a considerable depletion of Treg in both spleen and LNs and nadir was reached at 2 days after CY administration (the time we selected to deliver PDT).
Rubins et al [ 1] observed a considerable depletion of T cells, and a large number of apoptotic cells in the splenic periarterial lymphatic sheath, possibly due to the viral replication in antigen presenting cells in the lymphatic tissues, which could lead to apoptosis in the lymphocytes.
Cells lost their conventional elongated architecture and assumed a spherical, rounded-up appearance, evident of considerable depletion of vital survival and sustenance signaling that was otherwise provided by CK2.
AT-rich regions are known to disfavor nucleosomes [30], therefore a considerable nucleosome depletion at replication origins (∼−0.5 sd units below the genomic average) is in accordance with earlier small-scale experiments [31].
If the rate of deposition is increased, so as to produce near the surface considerable depletion of ions, uneven deposition will start.
Above 300 mg/L of initial phenol concentration no considerable depletion was recorded.
These samples also showed considerable depletion of organellar DNA in the methyl-rich fraction (5.6 20.3-fold).
Studies in humans have shown considerable depletion of the spleen from B lymphocytes and T lymphocytes at autopsy postmortem [ 15, 16].
CE‐MS analysis confirmed that both Gln deprivation and L‐ASNase treatment resulted in considerable depletion of intracellular Glu (Fig. 3a) and of three representative TCA cycle intermediates (i.e. α‐ketoglutarate, succinate and oxaloacetate; Fig. 3b) in Jurkat cells.
A similar trend was also observed in the treatment control groups (groups VII-IX).> -wrap-foot> a P < 0.05 compared with carcinogen control; b P < 0.05 compared with curcumin On the other hand, considerable depletion of GSH was noted in group II (0.61 ± 0.06 μg/mg liver tissue), in relative to group I (0.84 ± 0.05 μg/mg liver tissue).
