The phrase "a considerable defect" is correct and usable in written English.
It can be used to describe a significant flaw or shortcoming in something, such as a product, plan, or argument.
Example: "The report highlighted a considerable defect in the methodology that could affect the results."
Alternatives: "a significant flaw" or "a major shortcoming."
It is also the first report confirming that the GBR technique could be effective for treating long tubular bone defects, which remains a challenge for orthopaedic surgeons, and it may enable superior bony union across a considerable bone defect gap of almost 15 mm.
eco1Δ wpl1Δ cells by themselves display a considerable cohesion defect (Ben-Shahar et al. 2008).
In both media, the Δ parABc strain did not display a considerable growth defect.
DOI: http://dx.doi.org/10.7554/eLife.09073.019 We also examined glcs bearing a pygo null allele (Thompson et al., 2002), which revealed considerable defects in Eve and Ubx expression, and almost complete absence of Wg, as previously reported for a different null pygo allele (Parker et al., 2002).
The large magnitude of dark current density indicates that there are considerable defects and dislocations in the ZnO film grown on a Si substrate, which is a typical result of heteroepitaxy between largely mismatched materials [25].
Nevertheless, statues shouldn't be raised only to saints and Lloyd George, for all his considerable defects, was no Lucifer.
Furthermore, there were considerable defects in p24 CA release, in particular in the case of rodent cells.
The spin disorder is due to the presence of considerable defects which can destroy the superexchange interaction.
The present mode of supplying the army--by state purchases--is not one of the least considerable defects of our system.
It is seen that there are considerable defects of atom clusters caused by the thermal effect in both the aluminum and copper work piece, which essentially lower the critical force associated with the initial plastic deformation.
