The phrase "a considerable decrease in expression of" is correct and usable in written English.
It can be used in contexts discussing changes in levels of expression, such as in scientific or academic writing related to biology, genetics, or other fields.
Example: "The study revealed a considerable decrease in expression of the target gene after treatment with the drug."
Alternatives: "a significant reduction in expression of" or "a notable decline in expression of".
When compared with the original cell line, the WM-115-X xenografts, as well as the derived WM-115-CX cell lines, showed a substantial increase in the expression of CCR7 and CCR10, a considerable decrease in the expression of CXCR4 and a slight but significant decrease in the expression of CXCR3.
In contrast to FAT/CD36, we noticed a considerable decrease in the expression of FABPpm mRNA in obese SAT (−28%, P = 0.049; Fig. 2a), as well as obese VAT (−32%, P = 0.039; Fig. 2a) compared with the respective tissues in the control group.
However, the induction of EWS/ETS expression in human MPCs resulted in not only an increase in DKK2 gene expression but also a considerable decrease in DKK1 gene expression.
Multi-marker imaging, achieved during the same imaging session, indicated a significant increase of VEGFR-2 and αvβ3 integrin expression during tumor angiogenesis, as well as a considerable decrease in the density of both markers after treatment.
Our analysis of German consumption data revealed a considerable decrease in the consumption of antihistamines.
A considerable decrease in the amount of galactarate was detected in the gln1.3 mutant.
Each of the cell lines showed a considerable decrease in relative HML-2 expression compared with nonirradiated cells (fig. 6 b).
Deletion of the P. aeruginosa type III secreted exotoxins resulted in a considerable decrease in cytotoxicity, as compared to that of wild-type PAK-J strain, which allowed cells to remain viable and undergo gene expression changes after infection.
When we used a codon optimization program in an attempt to increase the expression of OCT4 and SOX2 at the protein level, we detected a 20 30% decrease in protein expression compared with wildtype genes, which unsurprisingly leads to a considerable decrease in reprogramming [12].
