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The phrase "a considerable burden of" is correct and usable in written English.
It can be used when discussing a significant amount of responsibility, obligation, or difficulty that someone is facing.
Example: "The new regulations imposed a considerable burden of compliance on small businesses, making it challenging for them to operate efficiently."
Alternatives: "a significant load of" or "a heavy weight of".
Exact(58)
Influenza-associated acute lower respiratory infections cause a considerable burden of disease in rural and urban sub-Saharan Africa communities with the greatest burden among children.
Decorated twice at the last Commonwealth games, Jazz Carlin will carry a considerable burden of expectation on her powerful shoulders to next summer's games in Glasgow, where she will compete in the long-course freestyle events that have become her speciality.
Frehner said: "The Board of Trustees and Directors of Kunstmuseum Bern are surprised and delighted, but at the same time do not wish to conceal the fact that this magnificent bequest brings with it a considerable burden of responsibility and a wealth of questions of the most difficult and sensitive kind, and questions in particular of a legal and ethical nature".
Introduction Relatives of patients who die in the ICU experience a considerable burden of harm such as symptoms of anxiety and depression, posttraumatic stress disorder (PTSD) symptoms and quality-of-life alterations.
There was a strong and consistent relationship between levels of deprivation and severity or extent of decay thus, there was a considerable burden of disease in socioeconomically deprived children who had dental caries.
As India's only current tour professional and most successful snooker player after his ground-breaking run to the 2013 Indian Open final, Mehta has a considerable burden of pressure and expectation to shoulder.
Eighteen heavily pretreated patients with lymphoma (17 HL, 1 primary cutaneous anaplastic large cell lymphoma) were enrolled, 15 of whom had a considerable burden of lymphoma characterized by multiple tumor lesions including extensive abnormal lymph node regions (range: 0 7) and extranodal disease involving the bone, lung, liver, pleura, mammary glands, kidney, and soft tissues.
There is also a considerable burden of history.
S. aureus bacteraemia is frequently associated with exposure to healthcare settings with MRSA causing a considerable burden of disease.
Similar(2)
Thus, the ageing population may cause a considerable burden for costs of CVD.
With regards to the effects of cold, several studies have suggested that there is a considerable burden in terms of mortality, especially in the elderly and in persons affected by chronic respiratory or cardiovascular diseases [ 5, 7, 10- 12].
More suggestions(15)
a sizable burden of
a major burden of
a large burden of
a great burden of
a notable burden of
a sizeable burden of
a tremendous burden of
a massive burden of
a considerable pressure of
a serious burden of
a big burden of
a considerable body of
a considerable period of
a considerable amount of
a considerable margin of
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com