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The phrase "a considerable breakthrough in" is correct and usable in written English.
It can be used when discussing significant advancements or discoveries in a particular field or area of study.
Example: "The researchers announced a considerable breakthrough in cancer treatment that could change the lives of millions."
Alternatives: "a significant advancement in" or "a major development in".
Exact(2)
Jimmy Knapp, general secretary, said the union could see "the prospect of a considerable breakthrough in our case".
Hehr, who is quadriplegic, also represents the riding of Calgary Centre and a considerable breakthrough in Alberta, which is traditionally hostile to the Liberal Party.
Similar(57)
The modest step was a considerable breakthrough for the court.
In order to improve bioactivity, biocompatibility and implant longevity, thin films which are having nano crystalline achieved considerable breakthrough in the field of biomedical sciences due to their exceptional physical and chemical properties (Holleck 1991).
Three innings later, the Mets achieved a more considerable breakthrough.
This matched case-control study showed a considerable number of breakthrough infections, resulting in modest VE estimates.
It lingers the breakthrough and reduces the amount of bypassed oil so that a considerable increase in oil recovery factor is observed.
In recent years, tight sandstone gas exploration and production have obtained considerable breakthroughs through the application of fracturing technologies.
Cuenca has a considerable trade in timber.
Running for a considerable distance, in fact.
A considerable number of breakthrough infections was observed.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com