The phrase "a considerable and significant" is correct and usable in written English.
It can be used when emphasizing the importance or magnitude of something in a formal context.
Example: "The study revealed a considerable and significant increase in productivity after the new policies were implemented."
Alternatives: "a substantial and meaningful" or "a notable and important".
Those axons that were remyelinated had thinner myelin sheaths (Fig. 4C), reflected in a considerable (and significant) shift in frequency distribution to much larger G-ratios (Fig. 4E).
Even in animal experiments, where physiological variables are tightly controlled, there is a considerable and significant difference in response between individuals.
There was a considerable and significant increase over time in use of the CURB score (a clinical prediction rule for predicting mortality from community acquired pneumonia, see table 6) (odds ratio 7.3, 99% confidence interval 1.4 to 37.7), but again differences were not significant between control and SPI2 hospitals.
The possible bias caused by non-response may be estimated based on the assumptions that non-respondents, for instance, had a possible asthma on average either five standard error units more often or five standard error units less often then the respondents, i.e., a considerable and highly significant difference.
Although the FE method has been developed to a considerable degree, and significant achievements have been seen in the fields of analysis of solids and structures, it is important to compare the accuracy of simulations by the FE method with those by the FD and BI methods for simulations of spontaneous rupture (Moczo et al., 2007; Galis et al., 2009, 2010).
Considerable and significant research1 has been conducted focusing on what students know about fraction ideas.2 However, much of the research looks at student understanding following some instruction.
Recently, various considerable and significant results on adaptive backstepping control for nonlinear systems have been reported in [1 6], and the references therein.
Considerable and significant variation of site of death was observed between cantons.
Considerable and significant differences were observed between physicians for the self declared extent of medical activity in primary care.
