The part of the sentence "a considerable adverse effect" is correct and usable in written English.
You can use this phrase when you want to refer to a significant or large negative consequence. For example: "The new rule had a considerable adverse effect on our business operations."
As the TKIs, SUN and PAZ are oral medications that are self-administered by the patient and show a considerable adverse event profile 7, 8, compliance effects are expected in real-world settings.
These variables, however, have considerable adverse effect on quality of bicycling from an ordinary citizen's point of view and thus need thorough investigation.
"The information provided to the minister identified in sufficiently unambiguous terms the inevitable and considerable adverse effect which the closure of the fund will have, particularly on those who, as a consequence, will lose the ability to live independently," she added.
The considerable adverse effect from bicycle vehicle interactions and hindrance from street vendors or on-street parking actives combined together mostly have made these segments to offer average to below average quality of services.
Confidence in the hip replacement is emblematic of the success of the UK healthcare system and its governance yet when a product such as the ASR™ produces considerable adverse effects, confidence in medical implants is damaged.
Although in a number of placebo-controlled prospective trials no considerable adverse effects were reported of omega-3 fatty acids, to prevent patients from experiencing nausea and gastrointestinal disturbances, they were advised to take fish oil pearls with meals and to keep them in a freezer [ 25].
Prevention of exacerbations remains a key therapeutic goal, but current treatments have only modest benefits and considerable adverse effects.
Absconding from hospital is a significant health and security issue within psychiatric facilities that can have considerable adverse effects on patients, their family members and care providers, as well as the wider community.
Frequency drift has considerable adverse effects on the inductively coupled power transfer (ICPT) system such as decrease of transmission power and distance, EMC interference, system detuning and performance deterioration, and deviated operation from system design requirements endangering the stability so that robust control of ICPT system remains an open applied research problem.
One explanation for this is that IFNα is associated with considerable adverse effects.
