Substitution of this residue for arginine (CD8-DOβ-KR), a conservative change for another positively charged amino acid, largely prevented MARCH9-induced downregulation (Fig. 1B).
Instead, once again, Democrats are responding to a Republican president as individual entrepreneurs trying to protect themselves against the traditional conservative charge of being "soft on defense".
Paul Krugman's effort to rebut the conservative charge of liberal bias in the academy ("An Academic Question," column, April 5) inadvertently confirms it.
Senator Ted Cruz led the conservative charge against Barack Obama's decision to use executive action to reform the immigration system on Thursday, adapting remarks by the Roman philosopher Cicero to accuse the president of wanting to "destroy the constitution".
Mr Mohajerani himself has been under pressure from the conservative-dominated parliament to rein in the press or face impeachment.Periodic bomb attacks in recent months, including one this week apparently aimed at the Intelligence Ministry, lend support to the conservative charge that Mr Khatami's policies are leading the country to chaos.
The conservative charge is that Americans today are reluctant to recognize that morality is hard work; that, wanting to forgive, we too easily forget, and in so doing, are too quick to give people a second or third or fourth chance.
Another ad in January championed Hatch as "leading the conservative charge to repeal Obamacare".
The speaker may well find himself trapped in a legislative impasse between conservative and pro-reform members, even though the reformers might have won a majority of the 270 seats in the parliament.Even if the parliament does manage to pass some reformist legislation, it will still face scrutiny by the Guardian Council, a conservative body charged with ensuring the Islamic purity of all laws.
Indeed, the Collegiate Network, which distributes some $200,000 a year in publishing money to 58 student newspapers, issues a handbook, "Start the Presses!" which explicitly counsels its conservative charges to "loosen up," to, in effect, get in touch with their inner Abbie Hoffman.
Islamic scholars tired of conservative charges that Muslims in the United States constitute a radical fifth column bent on subverting American values and obligated by their religion to launch jihadist terror attacks are fighting back by issuing a fatwa.
