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In conclusion, the c.2268dup mutation leads to the formation of normal and alternatively spliced TPO mRNA transcripts with a consequential loss of TPO enzymatic activity in Malaysian-Chinese patients with goitrous CH.
Recently, we identified the c.2268dup mutation in a Malaysian Chinese family with goitrous CH and showed that the mutation leads to the reduction in TPO protein expression with a consequential loss of enzyme activity.
The c.2268dup mutation leads to the formation of normal and alternatively spliced TPO transcripts with a consequential loss of TPO protein enzymatic activity in the dyshormonogenetic Malaysian-Chinese patients with CH.
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John Walker, chairman of the Federation of Small Businesses, said sky-high insurance payments also needed to be suspended and a more open assessment of compensation payments after banks were given the job of determining what constitutes a consequential loss.
Your missed flight was a consequential loss because it departed the day your daughter was admitted to hospital.
Instead, Sandel is interested in what he sees as a deeper and more consequential loss of our collective moral compass.
Mikkelsen is Lucas, a self-effacing nursery school teacher living in a close-knit rural town in Denmark, struggling with a bitter divorce and the consequential loss of his son, who currently lives with his ex.
8 Patients with untreated or untreatable advanced AMD invariably suffer from impairment of central vision, with consequential loss of social independence as a result of a concomitant inability to read, recognise faces, watch television or drive.
"Re: sacrifice: I'd say John Terry's alleged 12 minutes with Vanessa Perronocel (or was it 12 minutes with Fabio Capello?, I get confused) and the consequential loss of the England captaincy, the respect of his peers and the goodwill of an entire nation was a good example of little gain for a great sacrifice," says Ben Bamford.
The proliferating number of lawsuits causes not only an unaffordable cost of malpractice insurance (which patients end up paying for and drives many doctors into earlier retirement, with the consequential loss of much needed experience), but results in unnecessary and very costly over-prescribing.
To mitigate the consequential loss of biodiversity, novel approaches such as ecological engineering have been adopted to enhance the biodiversity on these artificial structures.
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