Sentence examples for a consequent role in from inspiring English sources

It is well-established that TCFs, such as Elk-1, play a critical role in transcriptional activation in response to extracellular signals and a consequent role in the growth and development of cells.

Fibroblast growth factor receptor 4 (FGFR4) belongs to the family of fibroblast growth factor receptors (FGFR1-4), which display multiple biological activities, including mitogenic and angiogenic activity, with a consequent crucial role in cell differentiation, development, hormonal and proliferative signaling in response to more than 20 known ligands[ 2, 3].

The mTOR signalling is involved in several age-related diseases, including cancer, diabetes, and neurodegeneration with a consequent important role in aging and lifespan control [ 58].

Up-regulation (Additional file 2: Table S1) and abundance of these scavengers in the AmCDUnigene set and the reported above interaction between them indicate the complex and redundant ROS scavenging pathways, which may play a central role in the consequent regulation of acclimation and stress tolerance in cold- and drought-treated A. mongolicus seedlings.

Our study suggests that in addition to the characteristic hydrogen bonding and hydrophobic interactions, the preformed architecture of the binding site and consequent shape complementarity play a decisive role in the high-affinity biotin binding of rhizavidin.

Phenotypic changes in proximal tubule cells (PTCs) are initial signs of DN (3, 4), and consequent tubulointerstitial damage plays a central role in the progression to end-stage kidney disease (5).

If mTOR inhibition and consequent PP2A activation play a role in the reduction of phospho-Ser129 h α-syn caused by metformin, other mTOR modulators, such as the mTOR inhibitor rapamycin, would also be expected to affect phospho-Ser129 h α-syn levels.

Extensive evidence in the literature indicates that both insulin resistance and consequent hyperinsulinemia have an important role in the pathogenesis of PCOS [16], [18].

In the past it was always a question of which U.S.-based company would play a role in regional development, Joe explains, but now "there is much more intra-Latin American commerce," with a consequent boom in the continent's aviation industry.

Mitochondrial dysfunction and consequent cellular energetic failure play a key role in the development of sepsis-related organs failure.

If apoptosis plays a major role in total cell death consequent to ischemia, i.e., its extent and distribution are substantial, it is possible that anti-apoptotic interventions could result in further increments in survival and reduction of morbidity after acute coronary syndromes precipitated by coronary occlusion.