This raises the possibility of convergent evolution of additional prolines and PXXP motifs in the p53 PRDs of humans and NMRs, two species which evolved an extended lifespan and consequent requirement for an enhanced DNA damage response.
What purpose (if any) might be served by the high endogenous influx of Na+ into the parasite and the consequent requirement for a high expenditure of ATP in maintaining a low [Na+]i is unclear.
In the previous issue of Breast Cancer Research, Duffy and Parmar report that accurate estimation of the rate of overdiagnosis recognizes the effect of lead time on detection rates and the consequent requirement for an adequate number of years of follow-up.
To meet the cells' consequent requirement for DHAP, the alga adopted a mechanism generally used in higher plants: inactivation of triose phosphate isomerase (encoded by Cpr001755.1 and Cpr003712.8 in Cp0710, Figure 4B) [ 35, 36], a key enzyme that catalyzes the isomerization between DHAP and glyceraldehyde 3-phosphate (GAP), directly linking glycolysis and TAG synthesis.
However, it is yet to be adopted as an instrument of choice in orthopaedic applications, mainly due to the high temperatures that can be generated at the cut site and the consequent requirement to use additional cooling.
The SW form of the disease was characterized by elevated 17OH-P concentrations and plasma renin activity (>4,50 ng/ml/h), onset of hyperkalaemia, hyponatraemia, dehydration and/or shock in the first month of life, with the consequent requirement of mineralocorticoids and glucocorticoids treatment.
Given the lack of diagnostic facilities, and the consequent requirement that children presenting to health facilities with persistent diarrhoea receive only presumptive treatment, we conducted a systematic review.
One of the main problems of islet transplantation is the massive cell death occurring after islet isolation and transplantation, with the consequent requirement of high number of islets in order to restore glucose homeostasis.
The differences are largely due to the fact that some trials included systematic CMV prophylaxis while others did not, and because of variations in the incidence of rejection and the consequent requirement for increased immunosuppression.
There is no doubt, however, that the new sensitivity to the use of coded samples and the consequent requirement for informed consent will impact on the design and execution of research studies using human biological materials.
