The side chain points towards the centre of a triple helix bundle and the change to lysine, with the consequent introduction of an unpaired positive charge, is likely to disrupt the packing of this helix bundle.
The development and consequent introduction of triptans represented an unprecedented revolution in migraine history, being the first successful attempt of rational and mechanism-driven treatment of migraine attacks.
Original to Kepler, however, and typical of his approach is the resoluteness with which he was convinced that the problem of equipollence of the astronomical hypotheses can be resolved and the consequent introduction of the concept of causality into astronomy – traditionally a mathematical science.
In the absence of PARs, the molecular mechanism that protects the unmethylated state of the Dnmt1 promoter is lost, with consequent introduction of new methyl groups onto the promoter CpGs, and silencing of the gene.
The theoretical risk of variant Creutzfeldt-Jakob disease and the consequent introduction of leucodepletion by UK blood services has significantly increased the cost of blood to the National Health Service.
But even there, O. glaberrima is rapidly being replaced by O. sativa as a result of the long and frequent droughts in the last few decades and the consequent introduction of fast growing Asian varieties by agricultural development projects (Linares 2002; Richards 1996).
The introduction we read definitely suggested an information revolution, and a consequent shifting social structure.
This periodicity could coincide with RV-A vaccine introduction and the consequent reduction of circulation of non-G2 strains.
The introduction of candles with self-consuming wicks in the latter half of the 19th century and the development of alternative methods of lighting brought about a consequent decline in the use of snuffers.
There has been a consequent surge in botched operations, with some patients sustaining irreparable damage.
So here we have a predicate, a consequent, and an alternative.
