Replicative senescence naturally happens to normal cells after a determined number of replicative cycles, first as a consequence of telomere shortening at each cell cycle because the mature differentiated somatic cells do not have telomerase activity.
Secondly, as a consequence of this progressive shortening starting in the deep part of the muscle, the deeper fibers may undergo greater stretching during tendon repair.
These observations led us to hypothesize that the chromosome transmitted is the normal autologous one and that, as a consequence of the telomere shortening during embryogenesis, it underwent a circularization process, ultimately leading to the formation of a ring chromosome.
Kitching won the Senate place as a direct consequence of Shorten's support.
"The information requirements and levels of voter sophistication to accomplish cross-party raiding are daunting; and the opportunities for pay-off are scarce," Paradis told lawmakers at a hearing of the New York State Senate Elections Committee in 2009, intended to weigh the consequences of shortening the deadlines for enrolling in a political party before a primary.
To elucidate the mechanistic details of telomerase regulation we engineered specific chromosome ends in yeast so that a single telomere could be suddenly shortened and, as a consequence of its reduced length, elongated by telomerase.
The high proliferative rate in many tumours often results in them having shortened telomeres as a consequence of rapid cell turnover outstripping telomerase-mediated telomere repair.
Telomere shortening, a consequence of repeated cycles of DNA replication is thought to be a critical trigger of senescence [ 6, 7] which also involves activation of two major tumor suppressor pathways, p53 and Rb [ 2, 8, 9].
This study demonstrates that differences in the worker age of transition to foraging are a consequence of the time spent performing each task being shortened or lengthened proportionally.
Replicative senescence in human cells results from telomere shortening as a consequence of each cell division [ 4].
