Our previous studies provided evidence that prelamin A accumulation in hMSCs leads to reduced lifespan in culture as a consequence of premature senescence of these cells [ 23].
These data suggest that the true cervical insufficiency occurs infrequently, and a short cervix more frequently occurs as a consequence of premature cervical remodeling as a result of a pathological process.
Similarly, transfusion of stored pRBC units may enhance fHb concentrations in patients after transfusion - for instance, as a consequence of premature intravascular rupture of the transfused erythrocytes, or due to the transfusion of the fHb-containing storage medium [ 8].
This, in turn, suggests that the changes in gene expression in primary fibroblasts expressing progerin are a consequence of premature senescence, rather than a direct consequence of progerin expression.
We have shown by a combination of gene expression studies and morphologic analysis that the cell cycle arrest observed with PDCD2 knockout in ESCs is not a consequence of premature differentiation.
As the focus was placed on adolescent pregnancy as a consequence of premature sexual intercourse, more than as a consequence of unprotected sex, the approach to contraceptive use among adolescents was inconsistent.
