The phrase "a consequence of mutant" is not correct and lacks clarity in written English.
It may be intended to describe an effect or result stemming from a mutation, but it needs additional context or modification to be clear.
Example: "The unusual growth patterns in the plants were a consequence of the mutant gene introduced during the experiment."
Alternatives: "an effect of the mutation" or "a result of the mutant gene".
This observed impairment of the UPS in R6/2 cell synapses [30] coupled with the finding that K48-linked polyubiquitin chains accumulate in R6/2, HdhQ150/Q150 HD knock-in mice and HD patient brains [7] suggests that while UPS impairment can occur as a consequence of mutant htt expression, it is not necessarily a global consequence of mutant htt expression.
Here, we have provided in vivo evidence for impaired drug metabolism as a consequence of mutant POR.
It might be that DNA methylation is a consequence of mutant IDH expression and that this phenotype contributes to AML development.
These findings indicate that the change in locomotor activities of tgMT mice was not due to a nonspecific effect of protein overexpression, but a consequence of mutant Seipin expression.
Accumulated β-catenin interacts with T-cell factor (Tcf) or lymphoid-enhancer factor (Lef) and translocates to the nucleus, in which it transactivates target genes including c- myc and cyclin D1 that are the potentially oncogenic [ 47, 60] in the cytoplasm or nucleus as a consequence of mutant Apc or β- catenin genesis frequently observed in early stages of colorectal carcinogenesis [ 61, 62].
It is possible to presume that the higher apoptotic rate in control plant cells after nocodazole treatments may be also a consequence of absence mutant microtubule protein(s) or mutant microtubule associated protein(s) which confer(s) resistance to IPC in N. sylvestris mutant lines.
To confirm that the absence of an association between human HSJ1a and soluble mutant huntingtin was not a consequence of rapid mutant huntingtin degradation and to determine whether the J-domain or UIM motifs of HSJ1a are integral to HSJ1a complex association, we expressed myc-tagged HSJ1a or point mutant variants in SK-N-SH cells.
Only one transgenic line, 13a, exhibited nondisjunction levels significantly different than the wild-type transgene, and this is likely a consequence of the mutant protein being expressed at lower levels than wild type (Table 1, Figure S2).
The here observed epimutations could be a direct consequence of mutant CpG sites or CpG methylation-associated sequences in their proximity (methylation quantitative trait loci ).
Motor neurons of wt-hVAPB mice did not show the ER abnormalities observed in VAPB-P56S transgenic mice, indicating that these inclusions are a specific consequence of mutant VAPB (Table 1).
This led us to try to establish whether the formation of stress granules in these cells was a natural consequence of mutant FUS localizing to the cytoplasm, or whether stress granule formation could be linked to the protein over-expression associated with transient transfections.
