The phrase "a consequence of downregulation" is correct and usable in written English.
It can be used in contexts discussing biological processes, gene expression, or regulatory mechanisms in various fields such as biology or medicine.
Example: "The reduced activity of the enzyme was identified as a consequence of downregulation in the signaling pathway."
Alternatives: "an effect of downregulation" or "a result of downregulation."
These phenotypes are thought to be a consequence of downregulation of Robo receptor by virtue of a sorting mechanism similar to the one characterized in vitro.
Recently, we demonstrated that this phenomenon is a consequence of downregulation of the chemokine receptor CXCR2 on the surface of circulating neutrophils.
This increase of adiponectin is opposite to the decreased levels found in non-RA individuals with obesity, which is a consequence of downregulation of adiponectin in obesity.
Interestingly, Jin and coworkers have proposed that these hypermethylation events occur early during development as a consequence of downregulation of TET enzymes and/or of REST transcription factor.
It is thus tempting to suggest that modified tH2B and H3 histones could have accumulated in the testis of CPA-treated rats as a consequence of downregulation of h2bs and th3 genes.
They also recognised that some tumour cells escaped detection and eventually caused cancer and proposed that the cellular composition of such tumours, driven by the selective pressure exerted by immune system, becomes serially less immunogenic (immunoediting), perhaps as a consequence of downregulation of the molecules that are required for immune recognition.
Similar signaling pathways may lead to the downregulation of metabolic genes in mutant U6atac flies as a consequence of prohibitin downregulation.
We recently demonstrated that this phenomenon is a consequence of the downregulation of chemokine receptor CXCR2 on the surface of circulating neutrophils.
72, 74– 76 Suppression of cancer cell proliferation as a consequence of SIRT1 downregulation might be attributable to telomere dysfunction and increased acetylation and subsequent activation of p53.
The increased risk of diabetes in FRDA patients is therefore likely to be a consequence of the downregulation of Pgc1a in key tissues for insulin response and fuel metabolism control.
In addition, flavocoxid reduced serum levels of PGE2 and LTB4 as a consequence of a downregulation of COX-2 and 5-LOX expression in lung and liver of mice subjected to CLP, implicating the same mechanism of action of flavocoxid as reported in our previous studies [ 17- 19, 23].
