Sentence examples for a consequence of destabilization from inspiring English sources
A previous study showed that genetic knockout of p53 in this model did not result in an accelerated pathway to tumor formation, and in fact, beta tumor cell proliferation was reduced, likely a consequence of destabilization of the SV-40 large T antigen oncogene, to which it binds [17].
Thus, loss of Taz1 is not simply a consequence of the destabilization of the MICOS complex or the loss of crista junctions.
In light of these points, it is possible that blood-cell DNA methylation is not simply a passive, irrelevant target of airborne environmental exposures: Blood-cell methylomic alterations may eventually contribute directly/indirectly to cardiopulmonary outcomes via mechanisms not yet well understood, e.g., via aberrant MAPK signaling as a consequence of (epi gene destabilization.
DOI: http://dx.doi.org/10.7554/eLife.07304.015 To ask if the change in oligomer size observed with pH is a consequence of dimer interface destabilization, the His-104 mutants were analyzed by SEC-MALS and EM at pH 7.5.
Except for Rand Paul, none of the Republican candidates has been willing to admit that ISIS is a consequence of our complete devastation and destabilization of Iraq -- leaving us with the greatest real threat the international community has faced for some time.
Several studies have shown that the rapamycin-induced feedback activation of AKT (Thr308) is a consequence of the absence of P70S6K destabilization on the adaptor protein insulin receptor substrate-1 (IRS-1).
They [9] suggested that the observed thermodynamic and kinetic destabilization is a consequence of the in situ formation of β and NaMgH3 phases during the dehydrogenation reactions of the MgH2 Na3AlH6 (or NaAlH4) (4:1) composites.
The destabilization that is a consequence of the presence of a ribonucleotide rather than a deoxyribonucleotide in both the pre-translocation and post-translocation states is at least in part due to a steric clash of the 2′-OH group with the phenyl ring of the highly conserved residue Y254; in both translocation states the destabilization is partially alleviated by the Y254V mutation.
The degradation in V2O5 was accomplished by destabilization of YSZ as a consequence of depletion of yttria from the solid solution to form YVO4 and therefore led to the disruptive transformation of the metastable tetragonal phase to the monoclinic phase.
We therefore predict a mild destabilization of the T-state as a consequence of the Leu or Cys replacement that might slightly increase the oxygen binding affinity of these variants.
67, 69 These findings are opposite to the previously reported destabilization of c-Myc by SIRT1 as a consequence of deacetylation of c-Myc through direct interaction between two entities.
