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The interviewees in our study talked about mastectomy as a consequence of breast cancer and few of them associated that with female body deformation and diminished femininity.
In this study cause of death was stratified on cardiovascular outcomes but the findings of Nyström et al. are nevertheless relevant even in this setting as they suggest that we are not likely to underestimate CVD deaths in this study as a consequence of breast cancer deaths being reported more frequently among the patients than they would in a disease free population.
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In the last 17 years, she had survived breast cancer, myelodysplastic syndrome (a consequence of the breast cancer treatment) and was now facing esophageal cancer.
As a consequence of mammographic breast screening programmes, ductal carcinoma in situ is diagnosed with increasing frequency.
Many comorbid conditions are identified as a consequence of the breast cancer diagnosis.
For instance, lymphedema, which is a common consequence of breast cancer, has a negative impact on patients' body image, ability to carry on with daily activities and social interaction.
Bone metastases, or the spread of cancer to the bone, are a serious consequence of breast cancer.
The raised risk that we found with late menarche could not directly be a consequence of the association between breast density and breast cancer risk, however, as this would also hold in the general population, in whom late menarche is not associated with raised breast cancer risk.
We have already shown that bcl-2 protein is down-regulated upon treatment of breast cancer cells with N-BPs (Senaratne et al, 2000) and now report that forced expression of bcl-2 in MDA-MB-231 breast cancer cells efficiently inhibits ZOL-induced DNA fragmentation, which is a consequence of caspase activation in breast cancer cells.
To further support a relationship between bcl-2 and N-BP mediated apoptosis, we now report that forced expression of bcl-2 abrogates ZOL-induced DNA fragmentation which is a consequence of caspase activation in breast cancer cells.
Future efforts directed at determining how overexpression of AIB1 affects cell behavior in the presence or absence of specific hormone receptors should shed light onto specific signaling pathways that are altered as a consequence of AIB1 amplification in breast cancer.
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