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A consequence of blocking CGRP could thus be alterations in wound healing and increased inflammatory responses in skin injuries at the site of injection for the antibodies.
As a consequence of blocking splice-donor sites three scenarios are possible: 1) the removal of the targeted exon, 2) the use of a cryptic splice donor site, often causing a premature termination codon, or 3) a retention of the targeted intron.
Zinc inhibits chloride secretion (cyclic AMP, nitric oxide, and possibly Ca2+ stimulated), most likely as a consequence of blocking basolateral potassium channels.
The effect may be a consequence of blocking the precapillary constrictor effects of ET-1 mediated by ETA receptors, as well as improved endothelium-dependent vasodilatation by enhancing the bioavailability of nitric oxide.
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Pharmacologic disruption of the S1P S1PR1 interaction ameliorates CIA as a consequence of blocked lymphocyte egress from LNs [ 40].
In MSC SHP-2 KO mice, based upon the phenotypes of ERK- and AKT-deficient mice discussed above, growth retardation is expected to be a consequence of blocked activation of both kinases.
Interestingly, female Cgl null mice exhibited significantly lower plasma tCys compared to WT control mice plus or minus PPG (P=0.001) and Cgl male mice indicating that plasma levels of this compound are significantly lowered as a consequence of severely elevated tHcy rather than as a consequence of blocked endogenous synthesis.
In contrast, these results argue that the precise precytokinesis arrest observed after the induction of VSG RNAi is a direct consequence of blocking VSG synthesis.
The increase in CD4+ T cell numbers associated with CCR5 inhibition could be a simple consequence of blocking the trafficking of CCR5+ T cells between circulation and peripheral tissues.
A major consequence of blocking digestion of carbohydrates in the proximal gut, colonic fermentation, can only lead to increased microbial production of gas in the bowel.
A functional consequence of blocking classic CD28-mediated co-stimulation with abatacept is that it also leads to inhibition of the proliferation of both circulating naïve and memory T cells [ 59].
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