A straightforward speculation is that the characteristic CBF distribution might be a consequence of abnormalities in the thalamus or basal ganglia, such as the lenticular nucleus, which are closely connected to several cortices.
Elevated IFP in tumors is partly a consequence of abnormalities in the microvascular network, and the architecture and function of the microvascular network may differ substantially among individual tumors of the same experimental line as a consequence of stochastic processes influencing tumor angiogenesis shortly after transplantation and during tumor growth.
Therefore, we considered that results obtained using iv/iv mice reflect a consequence of hippocampal abnormality.
The raising awareness that a disease is rarely a consequence of an abnormality on a single gene, but it is usually the result of complex interactions and perturbations involving large sets of genes and their relationships with several cellular components, lead to development of the "Network medicine", a network based approach to human disease [1].
It has been suggested that a disease is rarely a consequence of an abnormality in a single gene/protein given the functional interdependencies between molecular components in the cell [ 50], and that both network connectivity and dynamics are important targets for therapeutic intervention [ 51].
This coordination is selectively disrupted in a rat neurodevelopmental model of schizophrenia: fragmented NREM sleep and impaired slow-wave propagation in the model culminate in deficient ripple-spindle coordination and disrupted spike timing, potentially as a consequence of interneuronal abnormalities reflected by reduced parvalbumin expression.
MiRNA silencing in cancer can be due to several mechanism, as a consequence of genomic abnormalities or epigenetic regulation [35].
Although multipolarity is often a consequence of centrosome abnormalities in cancer cells, several studies have shown that the amplified centrosomes coalesce and form a bipolar spindle [1], [2], [3].
