a conformation is required

USAGE SUMMARY

The phrase "a conformation is required" is correct and usable in written English.
It can be used in contexts where confirmation or validation of something is necessary, such as in business or technical communications. Example: "Before we proceed with the project, a conformation is required from the client regarding the final specifications."

✓ Grammatically correct

Science

Human-verified examples from authoritative sources

Exact Expressions

1 human-written examples

Although the conformational features alone do not warrant an interfering activity, a double-helical RNA-like A conformation is required for effective gene silencing.

BioMed Research International

Human-verified similar examples from authoritative sources

Similar Expressions

59 human-written examples

A shift to an open conformation is required for binding to the cytoskeleton.

ASN Neuro

Earlier, we observed that insertion of helix-disrupting proline substitutions at residues 40 and 41 within the hA segment of fusion protein N30 hA eGFP stabilized the molecule, indicating that a helical conformation is required for maximal degron function [ 9].

Bioscience Reports

It will be interesting however to investigate ligand (ATP) binding capabilities of KSR1/2 and see if this is required for MAP kinase signalling, and whether an active conformation is required for KSR binding of macromolecular partners.

Current Opinion in Structural Biology

Therefore, a resting state conformation is required for a comprehensive understanding on the overall cycle of conformational change.

Protein & Cell

To test if an α-helical conformation is required, we introduced proline substitutions at residues 13 and 14 of the first helix, resulting in LACP/P eGFP (see Figure 1).

Bioscience Reports

In either case, a flexible or disordered conformation is required to enable degradation.

Chemical Reviews

To thoroughly explore how domain engagement influences SFK ATP-binding sites, a method for sensing ATP-binding site conformation is required.

Biochemistry

On circular nucleosome arrays (Fig. 3 and Fig. 4), a major change in chromatin organization and/or nucleosome conformation is required to absorb the topological constraint confined within such clusters.

Plosone

This suggested that the maintenance of protein conformation is required for lifespan extension and that a loss of protein homeostasis could contribute to aging.

Aging Cell

All of the factors that hamper dimer formation alter the hydrogen-bonding arrangement that is key for forming the "closed loop" conformer of the monomeric protein, leading to the hypothesis that the closed conformation is required for dimer formation and may in fact lie at the dimer interface; NO binding stabilizes the "closed loop" conformation, with its hydrogen bonds.

Biochemistry

Expert writing Tips

Best practice

When using "a conformation is required", ensure that the context clearly defines what entity needs to adopt the specific conformation and for what purpose. Be precise in describing the necessary characteristics of the conformation to avoid ambiguity.

Common error

Avoid using "a conformation is required" without specifying whose conformation is being discussed. The sentence can be confusing if it's not clear what entity needs to adopt the required conformation. Always provide clear context.

Linguistic Context

The phrase "a conformation is required" functions as a statement of necessity. It indicates that a specific spatial arrangement or structural state is essential for a particular process or entity. As Ludwig AI indicates, this phrase is grammatically correct and commonly used.

Expression frequency: Common

Frequent in

Science

100%

Less common in

News & Media

0%

Formal & Business

0%

Academia

0%

Ludwig's WRAP-UP

In summary, the phrase "a conformation is required" is a grammatically sound and frequently used expression, particularly within scientific contexts. Ludwig AI confirms its correctness and usability. It serves to highlight the necessity of a specific structural arrangement for a given process or function. When employing this phrase, ensure clarity regarding the entity needing the conformation and its purpose. Alternatives such as "a specific arrangement is needed" can be used depending on the desired nuance. Though common, avoid ambiguity by clearly defining the entity to which the conformation refers.

More alternative expressions

Phrases that express similar concepts, ordered by semantic similarity:

a specific arrangement is needed

Replaces "conformation" with "arrangement" and "required" with "needed", focusing on a particular spatial orientation.

a particular structure is necessary

Substitutes "conformation" with "structure" and "required" with "necessary", emphasizing the structural aspect.

a defined shape is essential

Replaces "conformation" with "shape" and "required" with "essential", highlighting the importance of the form.

a certain form is obligatory

Substitutes "conformation" with "form" and "required" with "obligatory", indicating a mandatory aspect.

a precise configuration is indispensable

Replaces "conformation" with "configuration" and "required" with "indispensable", stressing the exactness and importance.

a given spatial organization is crucial

Substitutes "conformation" with "spatial organization" and "required" with "crucial", expanding to a broader spatial aspect.

a set layout is mandatory

Replaces "conformation" with "layout" and "required" with "mandatory", focusing on the imposed nature of the arrangement.

a stable state is critical

Substitutes "conformation" with "state" and "required" with "critical", focusing on the stable and essential nature of the state.

a fixed positioning is vital

Replaces "conformation" with "positioning" and "required" with "vital", emphasizing the importance of precise placement.

a determined arrangement is paramount

Replaces "conformation" with "arrangement" and "required" with "paramount", emphasizing the supreme importance of the arrangement.

FAQs

How can I use "a conformation is required" in a sentence?

Use "a conformation is required" when describing that a specific spatial arrangement or structure is necessary for a process or function to occur. For example, "For the enzyme to bind effectively, "a specific conformation is required"".

What are some alternatives to saying "a conformation is required"?

You can use alternatives like "a specific arrangement is needed", "a particular structure is necessary", or "a defined shape is essential" depending on the context.

Is it better to say "a specific conformation is required" or "a specific conformation is needed"?

Both "a specific conformation is required" and "a specific conformation is needed" are grammatically correct and convey a similar meaning. "Required" implies a stronger necessity than "needed", but the choice often depends on the desired tone and context.

What does it mean when "a conformation is required" in a scientific context?

In science, "a conformation is required" typically refers to the three-dimensional arrangement of atoms in a molecule, such as a protein or DNA. This specific spatial arrangement is often essential for the molecule to perform its biological function. It means that without this structural state, the molecule will not work as it should.