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The limitation is that it is a conducted in one country, Australia, and thus its generalisability may be limited by prevailing institutional arrangements.
The immune response to YF, as measured by NTs 4 weeks after immunization, was different between the 2 studies, with a higher seroconversion rate, seroprotection rate, and GMTs (93%, 97% and 32, respectively, in study B conducted in Mali, vs 68%, 73%, and 14, respectively, in study A conducted in Ghana).
Subjects who were vaccinated with a single dose of 10 µg of PsA-TT at 12 23 months or 22 33 months of age in study A conducted in Mali and The Gambia; at 2 10 years, 11 17 years, or 18 29 years of age in study B conducted in Mali, The Gambia, and Senegal; and at 14 18 weeks, 9 12 months, or 12 18 months of age in study C conducted in Ghana are included in the current analysis.
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Rook points to a study conducted in Bristol, England, that surveyed 14,000 children born in 1992.
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