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The present in vivo studies demonstrate for the first time that the intrathecal delivery of BoNTB produces a prominent block of the evoked release of substance P from small primary afferents and a concurrent effect upon evoked pain behaviors.
Moreover, metabolomics profiling revealed a concurrent effect, with a number of gut microflora related metabolites being perturbed in multiple biological matrices.
We observed a concurrent effect of PPDH1 and PPDH2 on flowering, which agrees with the concurrent effect for these two genes found under a 12 h photoperiod [ 38].
The bioaccumulation of these compounds with age is well demonstrated, and a concurrent effect of maternal smoking could also contribute to this phenomenon.
A concurrent effect of accommodation response on trapezius muscle activity was observed with the minus lenses irrespective of whether incongruence between accommodation and convergence was present or not.
Assuming a concurrent effect of OC on immune markers, we conducted cross-sectional analyses of the data from the first of three surveys conducted in 1994/1995, 1996, and 1997.
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At site Gollin, summer drought is suggested to become an increasingly important growth limiting factor, as expressed by a pronounced negative effect of June temperature and a concurrent positive effect of precipitation in the period 1964 1993 (Fig. 4).
The authors accounted for the performance discrepancies by relating exercise task and duration to a decline in muscle pH and the concurrent effect on the rate of glycolysis.
It appears that different exercise protocols result in the selective activation of specific intracellular signaling pathways, which are most likely responsible for a concurrent training effect (see above).
This concurrent effect may compound pathophysiological effects due to a more sequential peripheral insulin resistance that is followed by hyperinsulinaemia and then beta cell loss.
Continuing drug use into older age may carry particular risks in terms of the concurrent effect on the brain; the brain changes in a number of ways across the life course, and the effect of these changes when combined with substance use are not well understood [ 13].
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