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For this regime the system of equations contains a concentration model that does not include concentration gradients, which is a departure from the classic Kynch theory for low ϕ0 (Kynch, 1952).
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Due to time lags between the production of toxin by microbes and the appearance of those toxins or their metabolites in edible fish and shellfish, developing a realistic concentration model is a difficult task.
From the preceding, the 90 min of data may be sufficient for obtaining a complete concentration model, the GDC.
In a previous risk assessment, various alternatives have been evaluated for linear extrapolation, including truncation of the RR at concentrations of 30 or 50 µg/m (assuming a linear function at up to 30 µg/m with no further risk increase at concentrations beyond 30 µg/m) and a log concentration model [5].
Since the GDC model is an actual concentration model, it does not have to decay several half-lives in order to obtain model parameters or validate the methodology.
Three different kinetic models, a simplified soft model, a concentration-based model and an activity-based model were developed and validated against the experimental data and by a penetration type mass transfer model in order to analyze the absorption rate and understand the reaction process.
One combined value and four unrelated washout-only models were tested and exhibited R-squared values for MRT with the GDC, i.e., a more complete concentration model, ranging from 0.0183 to 0.9395.
Using a maximum effective concentration model, neutropenia was proportional to exposure.
The current work is possibly a first application of a GDC radioactivity (or concentration) model.
The differences between the measured and estimated air pollutant levels may be partially explained by the fact that a point measurement is compared to a mean concentration modeled in volumetric grid cell.
To investigate whether a more detailed consideration of spatial variations in sediment concentration could affect our results, we developed a spatially variable sediment concentration model based on measurements in our site46, which includes three mangrove sites and six saltmarsh sites (Table 1).
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