Sentence examples for a compromised function from inspiring English sources

Because DSBs should be repaired by the homologous recombination (HR) pathway, the anti-cancer mechanism of PARP inhibitors is closely related to a compromised function of the HR.

The combination of the postulated shift of the intestinal flora and the high parasitic burden inevitably leads to a reduction in fitness, due to a compromised function of the intestine.

Alternatively, the weaker interaction capacity of GRCD1, compared to other GRCD proteins, could indicate a compromised function, easily competed out by other components necessary for stamen development and eventually leading to release of the developmental arrest in central flowers.

The role of these proteins in aging was underscored by the fact that a compromised function of different RecQ helicases in several human genetic disorders does not only lead to cancer predisposition, but also to various progerias, among them Bloom's and Werner's syndrome.

Because the G273X mouse model, which lacks the entire MeCP2 C-terminus, has a median survival of 28 weeks (Baker et al., 2013)—longer than both our R306C transgenic and the recently published R306C knock-in (median survival 18 weeks, this study, Lyst et al., 2013)—we hypothesized that the R306C allele must have an additional compromised function beyond its inability to bind NCoR through its TRD.

Nevertheless, this scale is very useful since it suitably describes the functional limitations of a patient with compromised function of the cervical spinal cord.

It is noteworthy that our behavioral assay system was able to detect a phenotype that potentially resulted from the compromised function of a single gene product, PLC-β2.

The deficits in development at 2 years of age may be educationally meaningful because compromised function at an early age may have a negative impact on subsequent school performance (Drillien et al. 1988).

Although results are interpretable only on the group level, the improvement in developmental outcomes and the lack of significant associations between PAH DNA adducts and deficits in development in the 2005 cohort may be educationally meaningful, because compromised function at an early age may have a negative impact on subsequent school performance (Drillien et al. 1988).

Individuals with spastic muscles present severely compromised function due to a diminished range of motion, diminished voluntary strength, and increased joint stiffness [ 13].

However, there is no definitive evidence that an ideal posture exists [ 29], or that deviations from an ideal norm are associated with compromised function and disability [ 12, 22, 23, 30].