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The threshold of toxicological concern (TTC) of a compound represents an exposure value below which the associated human health risk is considered negligible.
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We previously showed that GNF-5, a compound representing a novel class of allosteric Bcr-Abl inhibitors, specifically binds to the myristic acid binding pocket [25].
Each ECFP feature of a fingerprinted compound represents a circular substructure around a center atom.
A microarray profile of alterations in gene expression associated with a single compound represents a unique signature that can be used to detect compounds with endocrine-disrupting activity in the environment.
The evaluation of a compound is associated with a certain cost while the identification of an active compound represents a gain.
Similarly, the substitution of anion X− by Y− in an A+X− compound represents a simple anionic substitution; this is exemplified by the replacement of Cl− (chlorine ions) with Br− (bromine ions) in the structure of KCl (potassium chloride).
Resistance to the streptogramin A and B combination QUI/DAL is of concern since the compound represents an alternative to glycopeptides in therapy of human MRSA infections.
Compound represents a chemical compound.
Therefore, this unique compound represents a blueprint for the design of protease class-spanning inhibitors.
Thus this compound represents a new lead for possible development as treatment for TBI and related neurodegenerative disorders.
The hybrid cerium porphyrin compound represents a single-framework coordination polymer of open three-dimensional architecture, sustained by a continuous coordination synthon throughout the crystal.
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