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At issue is a compound named Simalikalactone E SkEE), isolated by IRD researchers from Quassia amara, a small red-flowered tree native to Central and South America.
Speculation on the Internet focuses on a compound named BIA 10-2474, which, according to Bial's website, is a candidate drug for "neurological and psychiatric pathologies" that is currently in phase I testing.
It is worthy of noting that we recently identified a compound, named MIBE, that exhibits the peculiar feature of acting as an antagonist ligand of both GPER and ER in breast cancer cells (Lappano et al., 2012a).
A compound named butyrolactone, a product for γ-hydroxybutyric acid (GHB), also known as 4-hydroxybutanoic acid, a naturally occurring substance found in the CNS, as well as in wine, beef, and citrus fruits, increases the levels of the insulin-degrading enzyme (IDE), suppresses autophagy via the mTOR pathway, lowers Aβ levels and prevents AD-like cognitive deficits in APP/PS1 mice [ 71].
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Rotenoids are isoflavonoids derivatives, with a prototype compound named rotenone, which is a mitochondrial inhibitor.
A synthetic compound named efsevin was identified from a suppressor screen due to its potent ability to restore coordinated contractions in tre.
The ruling party of Greece has softened Athens' stance from completely forbidding the use of the name "Macedonia" for FYROM to allowing it in a compound name that distinguishes it from regions of the same name in both Greece and Bulgaria.
The Willie Horton commercial of 1988, financed by a third party to the benefit of Bush's father, then vice president, and the negative Democratic advertisements of 1996 -- which juxtaposed Bob Dole and Newt Gingrich, tinted them a sickening green, set them to bone-jarring music and called them by a compound name (Dolegingrich) -- were lineal descendants of the daisy ad.
Some analysts have suggested that referring to her by a compound name, following an outdated tradition sometimes still used by Chinese who live outside mainland China, hints that she has or had foreign residency, violating the rules governing senior leaders and their families.
Xunzi pointed out that sometimes we refer to things by a single name, such as 'horse', and sometimes, to communicate more precisely, we use a "compound " name (what we would think of as a noun phrase), such as 'white horse'.
Crenolanib is an example of the situation where earlier publications mention a compound name and the target but the chemical structure is not given (e.g. the publication [26] with the Pubmed ID 19738123 in September 2009 mentions CP-868,596, a synonym for Crenolanib, but no structure was specified).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com