Sentence examples for a component of focal from inspiring English sources

We first stained vinculin, a component of focal adhesions, in order to visualize these focal adhesions.

(b) The blockage of β1 integrin, a component of focal adhesions which connect stress fibers and extracellular matrix, resulted in disoriented cell division directions and a loss of DF.

A key regulator of focal adhesions is the adaptor protein vinculin, which is a component of focal adhesion contacts and an anchor for actin filaments.

They later showed that in immortalized human keratinocytes (HaCaT cells) loss of EP2 receptor expression was associated with increased invasiveness and decreased expression of paxillin, a component of focal adhesion complexes [ 50].

Integrin linked kinase (ILK) is a component of focal adhesion plaques [ 62, 63], and has direct effects on actin modification through the phosphorylation of cofilin, where it acts to block the actin-severing effect of unphosphorylated cofilin [ 64], and integrin stimulation triggers signaling through this kinase [ 65, 66].

Four-and-a-half LIM domains protein 2 (FHL2) is a component of the focal adhesion structures and has been suggested to have a role in cancer progression.

We have also found that the actin cytoskeleton and the distribution of αvβ3 integrin, a critical regulator of angiogenesis and a major component of focal adhesions, were disturbed after MVL-PLA2 treatment.

In a mammalian cell culture system, RNF5 has been shown to ubiquitinate and regulate the localization of the protein paxillin [22], a critical component of focal adhesion, involved in cell adhesion and motility.

EDA2R protein negatively regulates focal adhesion kinase, a central component of focal adhesion.

Vinculin is a prominent component of focal adhesions and it induces integrin clustering and focal adhesion formation through interactions with talin, an actin-integrin linkage protein [ 21].

ILK, a key component of focal adhesion complex, binds to the cytoplasmic domain of β1 and β3 integrins and several key actin binding proteins and adaptors [ 12].