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Since the description of SCD as a clinical entity nearly a century ago, investigations into the pathophysiology of VOC have been dynamic and manifold, leading to the delineation today of a complex process, encompassing interactions between sickle red blood cells (RBCs), white blood cells (WBCs), endothelium, plasma proteins, and several other factors (Frenette & Atweh, 2007).
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We need to understand that our decision making is a very complex process, encompassing not only our knowledge and desire, but also much input from other sources.
Validation of an assay is a complex procedure encompassing the determination of its reliability and relevance.
The design of a cellular network is a complex process that encompasses the selection and configuration of cell sites and the supporting network infrastructure.
Modeling such a complex process must encompass multiple scales, in space from cells to tissue, as well as in time, from minutes for the tissue mechanics to months for healing.
Elastogenesis, one of the crucial components of the development of the aorta, is a complex process that encompasses transcriptional and posttranscriptional regulation as well as coordinated assembly of multiple molecules in the extracellular milieu.
Hepatic sterol homeostasis is a complex process that encompasses de novo synthesis of cholesterol, secretion and uptake of lipoproteins, conversion of cholesterol to BAs, and bile secretion.
Studies have shown that SRH reflects a complex process of internalized calculations that encompass both lived experience and knowledge of disease causes and consequences [ 13].
The grieving process is a complex process.
Developing a vaccine is a complex process.
"This has been a complex process.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com