Sentence examples for a complex milieu from inspiring English sources

Nevertheless, fibrin presents a complex milieu of signals to embedded cells, many of which are not well understood.

Gastrointestinal fluid is a complex milieu and it is recognised that gut drug solubility is different to that observed in simple aqueous buffers.

One example is the external region of a cell membrane, known as the glycocalyx, which is dominated by a complex milieu of glycosylated molecules.

This is especially important in the context of inflamed tissues where activated Treg cells must preserve their core gene expression program in the face of a complex milieu of extracellular cues.

It requires working at and across the boundaries between knowledge types — a complex milieu of different value systems, norms, and mental models — and multiple stakeholder-engagement processes which facilitate knowledge exchange and co-production.

The microenvironment of the neuron becomes a complex milieu in which high levels of glutamate provide a source of chronic excitatory neurotoxicity, and the contributions of activated microglial cells lead to further cascades of motor neuron death, perhaps serving to propagate the disease once established.

Recruitment of inflammatory cells, endothelial cells and myofibroblasts to the metastatic niche leads to a tremendously complex milieu of growth factors, chemokines, hormones, enzymes and ECM that can promote stem/progenitor cell traits [ 97, 98].

To study the effect of CX on vascular morphogenesis and functionality in a relevant, yet less complex milieu than that of a tumor, we turned to the rabbit hind limb model.

Within this complex milieu, a number of credos uneasily co-exist.

However, it is inherently difficult to define the complex milieu of an infection site, and the assays used here were sufficient to define differences between material types.

Telomeres function in the context of a complex nuclear milieu in which telomeres tend to occupy distinct subnuclear regions.