We suspect it to be unlikely that ribosome pausing is caused solely by dramatically large defects in peptidyl-transfer, but instead may result from ribosomes that become effectively inactivated (e.g. as a result of complex instability on homopolymeric A messages, etc).
Examination of ORC by EM after negative staining showed a monodisperse population of particles, with no indication of complex instability at the low-nanomolar concentrations used for sample deposition onto EM grids.
Despite the absence of detectable biochemical abnormalities, immunofluorescence staining with antibodies specific for subunits of the five respiratory chain complexes showed many muscle fibers with reduced expression or total absence of individual complexes, presumably reflecting complex instability in the absence of mtDNA-encoded subunits.
Analytical modeling provides a quick first insight into the critical conditions at the onset of folding; yet, it fails to predict the evolution of complex instability patterns in the post-critical regime (Ben Amar and Goriely 2005).
In the case of complex instability, relased 99mTc-pertechnetate accumulates in these organs (Zuckier et al. 2004).
To solve the problem of aptamer protein complex instability during extraction, we previously proposed a chemical fixation between an aptamer and its target by incorporating nucleotides that cross-link with their target via UV irradiation.
DAG complex instability leads to mislocalization and downregulation of nNOSμ; but this is thought to play a minor role in disease pathogenesis.
For years George III's insanity was put down solely to porphyria; it is now believed he suffered from a complex range of mental instabilities.
Heterogeneous methylation is a complex phenomenon suggestive of epigenetic instability due to incomplete methylation of alleles; however, it is poorly understood and variably detected by existing methodologies [ 102].
ANTANANARIVO, Madagascar, 7 April 2009 – A complex web of cyclones, drought and political instability is seriously threatening the survival, development and protection of children in Madagascar.
