Biochemical and genetic studies have identified that PcG complexes can be functionally separated into at least two distinct complexes: an initiation complex, PRC2, and a maintenance complex, PRC1.
It has been suggested that the granuloma formation represents a complex process involving initiation and development of organized multicellular structures comprised of macrophages, CD4 and CD8 T cells, dendritic cells as well as components of extracellular matrix (ECM) [2].
In fact, carcinogenesis of prostate epithelial cells results from a complex series of initiation and progression events under environmental and genetic factors [ 3].
EIF3B is a major scaffolding subunit of the eukaryotic translation initiation factor 3 (eIF-3) complex, a complex required for the initiation of protein synthesis.
Collectively, these results suggest that FACT has a specific function in rDNA transcription by Pol I and, crucially, that FACT appears to function at a stage following pre-initiation complex formation, initiation of transcription and transcription of the first 40 nt.
Autophagy plays a complex role in tumor initiation and progression.
Specifically, we determined if Ybx1 forms a complex with the translation initiation machinery and sqt RNA.
A complex regulatory network triggers initiation of seed maturation and corresponding accumulation of storage products.
More specifically, the alcohols target translation initiation, a complex stage of the gene expression process.
