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Lyme disease is a complex infectious disease, caused by spirochetes of the Borrelia burgdorferi sensu lato family.
However, with the recognition that chronic periodontitis is a complex infectious disease associated with polymicrobial biofilms, more emphasis is currently given to the study of subgingival bacteria in the context of a community [ 16].
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To inform this model, baseline data will be collected to allow a more complex infectious diseases model to be built if the intervention is proven.
Leprosy, an ideal model of a chronic human complex infectious disease, provides an opportunity to dissect the components of the host-dependent polygenic susceptibility to this disease.
When faced with an unknown or complex infectious disease, multiple conventional diagnostic tests are often used, potentially leading to unnecessary costs and delays in diagnosis.
In conclusion, our results show that the integrated approach of the systems biology, that we have applied for studying the mechanism of the bacterial resistance to methicillin at biochemical level, can be very useful to a biological modelling of complex infectious diseases.
For complex infectious diseases, e.g., tuberculosis, a mild effect of many contributing genes is more expected; therefore we adopted the OR of 1.5.
A multi-control measure model developed here could be implemented in more complex infectious circumstances.
On the other hand, success of S. sonnei is warranted also in developed countries by low infectious minimal dose, high secondary attack rates and, in comparison with the other serogroups, a better capability to survive to stressing environmental conditions and exploit alternative and more complex infectious routes, such as food vehicles [ 33- 35].
Seaman says she's anxious to see how far the money will push efforts to fight complex infectious disease in the bush.
These results underline the necessity of adapting vaccination strategies to control complex infectious diseases when CD8 cellular responses are crucial.
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