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The phrase "a complex disease" is correct and usable in written English.
It can be used when discussing medical conditions that involve multiple factors, symptoms, or causes, indicating that the disease is not straightforward.
Example: "Diabetes is often considered a complex disease due to its interplay of genetic, environmental, and lifestyle factors."
Alternatives: "a multifaceted illness" or "a complicated condition."
Exact(60)
Cancer is a complex disease.
"But this is a complex disease.
Schizophrenia constitutes a complex disease.
"For anybody else, it is a complex disease," she says.
AD is a complex disease with multifactorial etiologies.
Acute ischemic stroke is a complex disease.
Migraine is a complex disease with a significant genetic background.
Miklos, G. L. & Maleszka, R. Microarray reality checks in the context of a complex disease.
Definitively diagnosing Alzheimer's is a challenge, researchers say, because it's a complex disease.
This is a complex disease, and you can't just flip one switch.
A genotype-first approach to defining the subtypes of a complex disease.
More suggestions(16)
a tricky disease
a multifaceted disease
a complex illness
a complex contagion
a challenging disease
a complex health
a problematic disease
a complex infection
a difficult disease
a multi faceted disease
a compound disease
a very complicated disease
a complex ill
a complex infectious
a complicated disease
difficult the disease
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com