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The phrase "a completely different course" is correct and usable in written English.
It can be used to describe a situation or path that is entirely unlike another, often in the context of decisions, plans, or educational paths.
Example: "After much consideration, I decided to take a completely different course in my career, focusing on environmental science instead of finance."
Alternatives: "an entirely different path" or "a wholly distinct direction".
Exact(9)
"It is a completely different course than we played in the practice round," Spieth said.
"This is a completely different course to what anyone else is doing".
I only played Pebble when it was perfect, and it was a completely different course.
Ms. Raitt's career has followed a completely different course from Ms. Lauper's.
In England the development of a "national" education took a completely different course.
Meanwhile, Kik has stayed independent and is charting a completely different course.
Similar(51)
You could make the same film in a completely different form, of course about the Islamists of today.
"It's a nice position to have played well last week, to have been in the last group with a chance to win and again to come back this week, completely different course, and have another shot to win," Kuchar said.
Here, it's a completely different golf course.
She's now undead, which really freaks out a paramedic on the scene and sets her on a completely different "life" course.
The close relationship between intestinal damage and inflammation was further underscored by the fact that NMA resulted in only a modest inflammatory response with a completely different time course, and the virtual absence of severe intestinal damage.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com