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The phrase "a completely different alignment" is correct and usable in written English.
It can be used when discussing variations or changes in positioning, perspective, or arrangement in various contexts, such as in design, strategy, or personal beliefs.
Example: "After reviewing the feedback, we realized that our goals were in a completely different alignment from the client's expectations."
Alternatives: "a totally different arrangement" or "a wholly distinct alignment".
Exact(1)
NY 10 was assigned in 1924; however, it initially followed a completely different alignment than it does today.
Similar(59)
In GAML, we filter PacBio reads by a completely different approach, which is based on alignments, rather than k-mers.
There is a yet underexplored alignment-free metabarcoding approach that works under a completely different methodological basis the compression-based approach.
With a completely different flavor.
A completely different tour".
A final is a completely different game.
I feel like a completely different player".
He seems a completely different horse".
This is a completely different team.
It gives me a completely different perspective.
In a completely different mood comes Impossible!
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com