Since the availability of nutrients in the macrophage or animal host has not been completely delineated we have used an approximate representation based on that indirectly inferred from existing literature (see Additional file 6).
Abdominopelvic organs were outlined manually on axial CT images using the curved ROI tool in Osirix, a process that was repeated on adjacent slices until the organ was completely delineated.
The mechanism of activation of Akt-associated to β-arrestins is not completely delineated.
The susceptibility of critically ill patients to nosocomial infections is well described [40], yet its causes are not completely delineated.
Nevertheless, the mechanisms underlying the antitumour activity of oridonin have not been completely delineated.
However, the role of chemokines specifically on B cells in RA has not been completely delineated.
Although we have not completely delineated the mechanism by which BACE1 modulates glucose uptake, our results indicate a key role for APP-cleavage products.
Data from a number of studies, however, suggest that the kinase and GTPase activities of LRRK2 are intimately linked, although the exact nature of this relationship remains to be completely delineated [43 45].
Despite their great phylogenetic distance, we choose to perform this comparison against the zebrafish, Danio rerio, downloaded from Ensmbl on 6/15/2012 [ 17] as the transcriptome of this well-studied model species is presumably near completely delineated.
The conduct of multinational trials accelerates patient recruitment and enables broader registration and eventual patient access, but it introduces variables that have not been completely delineated and are incompletely understood.
Although the role of p53 in CSCs of GBM has not been completely delineated, in addition to MGMT down-modulation shown here, it has been suggested that p53 controls the differentiation, self-renewal and tumorigenic potential of GBM CSCs by negatively regulating the GLI1-NANOG network.
