Exact(2)
However, in those patients with sufficient β-cells available for salvage, the achievement of a stable glucose control with low doses or a complete discontinuation of insulin therapy that is offered by AHSCT appears worthwhile.
Glyburide (glibenclamide) was titrated from a starting dose of 0.2 mg/kg/day to 1 mg/kg/day, which resulted in a complete discontinuation of insulin after 6 days.
Similar(58)
However, the presence of a 90-day gap is not a measure of complete discontinuation; 87% of patients with a 90-day gap had a mealtime insulin claim following the gap.
From W28, GCs were tapered on a weekly basis by leaving out one daily dose each week over a period of 6 weeks until complete discontinuation.
The fluticasone 2000 μg/day arm followed a program with step-down and eventually complete discontinuation of corticosteroids.
However, in the 2-week treatment analyses we included only patients treated with ICS, and in the 1-year treatment analyses we excluded one group of patients who were treated according to a program with step-down and eventually complete discontinuation of corticosteroids, which is not in agreement with the current guidelines.
Some patients have completely discontinued insulin after starting GLP-1RAs, but the results of the Association of British Diabetologists audit revealed that complete discontinuation of basal insulin, upon initiation of exenatide treatment, led to a worsening of glycemic control for ∼50% of patients.
Complete discontinuation of acid-suppressive medications has been a common end point in many studies evaluating surgical or endoscopic anti-reflux therapy.
Nonetheless, flushing remains a problem with ERN; treatment must be initiated at a low dose (375 mg in Germany; 500 mg in the USA) and complete discontinuation remains common.
The outcome was even better after complete discontinuation than low-dose caffeine consumption.
Intermittent treatment: complete discontinuation of chemotherapy and targeted drugs.
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