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According to the present diagnostic (IHS) criteria except the one stating that a complete and persistent response to therapeutic doses of indomethacin is a must, all three of our cases presented phenotypically as HC.
A complete and persistent response to indomethacin was included as a pre-requisite criterion for the diagnosis of HC by the classification criteria of the IHS in 2004 [1].
A complete and persistent therapeutic benefit was observed after a single administration [ 15].
This combination treatment provides a complete and persistent regression of engrafted human carcinomas under conditions in which the virus alone was not fully effective even at 20-fold higher dose.
Due to irreversible COX-1 inactivation and the fact that platelets have limited capacity for de novo protein synthesis, the administration of low-dose aspirin every 24 h causes a complete and persistent inhibition of COX-1 in platelets associated with a limited and rapidly reversible inhibitory effect on COX-2 expressed in nucleated cells (Patrono et al., 2008).
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In contrast, loss of both pdx1 and hb9 leads to an essentially complete and persistent absence of beta cells.
Finally, we report that correction of the hemophilia phenotype using AAV1-F9 was complete and persistent (over 8 months), a result that underscores the value of continued exploration of alternative AAV serotype vectors.
Herein we report one case of primary disabling BMS, previously refractory to multiple regimens, with complete and persistent improvement with pramipexol, a nonergot dopamine agonist which has high selectivity for dopaminergic D2 receptors.
To confirm if complete and persistent loss of Dll4 causes organ toxicity, we used a conditional, endothelial-specific Dll4 knock-out mouse line (Dll4 lox/lox Cre+), in which Dll4 deletion is dependent on tamoxifen administration.
Plasma exchange was stopped after complete and persistent absence of haemolytic microangiopathic anaemia.
As shown, IAPa treatment resulted in the complete and persistent loss of cIAPs within minutes.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com