In addition, assessment of another sGC activator, A-350619, and complementary evaluation of an inhibitor of phosphodiesterase activity did not reveal the expected differences (Additional file 3: Figure S1B).
For these reasons, ROC curves alone are not suitable to give a complete picture on the actual performance of the connectivity estimation methods, thus, motivating the introduction of a complementary evaluation method: the PPC.
The use of a quantitative and a qualitative approach in combination increases the opportunity for a complementary evaluation, which provides a better understanding of GSD-Y's potential to influence the process of improving glycaemic control and life skills than using either approach alone.
As a complementary evaluation, we also quantified the statistical significance of the differences in association scores between the two conditions in an uncoupled manner (i.e., batching together measurements from different cells) for the protein pairs together and for the protein pairs individually.
The present work investigates a novel methodology based on complementary evaluation of UDC in marine environments by electrochemical impedance spectroscopy (EIS) and electrochemical noise (EN) analysis using Hilbert spectra.
Nevertheless, studies to evaluate the mechanism of the drug effect would benefit greatly from complementary evaluation of specific RNA transcripts in tissue that are both reproducible and have a wide dynamic range (i.e. 10-fold differences for Q-PCR).
In June 1999, the European Committee for Proprietary Medicinal Products (CPMP, now the CHMP) adopted an Opinion recommending the temporary suspension of the Marketing Authorizations for sertindole and asked for a complementary benefit/risk evaluation of the product [ 12].
Radiology of disorders of thyroid, parathyroid glands and complementary evaluation with nuclear medicine techniques (BK).
A complementary diagnostic evaluation can be performed by immunohistochemistry, western blot or ELISA but none of these methods can detect scrapie during the incubation period without autopsy.
