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Previous expression profiling that was conducted with small patient numbers showed a common gene expression signature and reduced number of differentially expressed genes between IGVH subtypes [ 7, 8].
This study was designed to identify a common gene expression signature in dilated cardiomyopathy (DCM) across different microarray studies.
Collectively, our results point to a common gene expression signature in MM mediated by gene silencing via the PRC2 complex.
From these genes, none belonged to a common gene expression group, which makes the finding of correlated expression stronger.
In contrast, all molecularly defined NSCLC subtypes share a common gene expression profile which is distinct from the other subtypes.
Finally, analysis of merged normal hematopoietic progenitor cell gene expression datasets led to the discovery of a common gene expression signature characteristic of these cells.
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It is not known whether these second hits cooperate with the first hit in a convergent manner, to produce a common gene-expression profile, or whether they provide a diversity of potentially overlapping cell states.
In conclusion, these results corroborate the biological expectation that same cell-types (MSCs) with different tissue origin (BM- versus PL-) would have a main large common gene expression footprint with a small differential gene expression signature, and –in such differential signature– most of the genes would be different because they present alternative spliced isoforms.
A Venn diagram displays common gene expression between gametes and representative EST libraries [ 31] of vegetative gametophyte and sporophyte tissues (corresponding to 9,163 annotated genes).
Keshava and Caldwell (2006) contended that it is difficult to identify a clear pattern of common gene expression changes for TCE and PPARα agonists in general.
It is difficult to discern a clear pattern of common gene expression changes among TCE and its metabolites or for peroxisome proliferators in general for use in making inferences regarding common MOAs.
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